Verse 53

अकृत्रिममहादुःखे संसारे ये व्यवस्थिताः ।त एतेऽन्यानि दुःखानि जानते मधुराण्यलम्

In plain words

Those who are established in saṃsāra—itself a great sorrow, and no fabrication—these very ones come to know all other sorrows as sweet indeed.