In plain words
These five kleśas seize man and torment him.
The five kleśas that stand in the way of man's Ānanda
Avidyā kleśa: the śāstra put a question, ‘Kasya mūrkhaḥ?’ Who in this world is the fool? That is the question it put. The śāstra in turn gave the answer to that very question. ‘Mūrkho dehādyahaṃ buddhiḥ’: the fool is the one who believes, “The body is I.” Sunk in folly, thinking he is the body, man forgets his own svarūpa and moves away from Ānanda. “I am not the body. I am the Ātma, the witness of body, Manas, Buddhi and the senses alike”: only on the day he can recognise this can he be blessed with this Ānanda. Body, Manas, Buddhi and the senses are all merely instruments. These are what have been called the karaṇas. To take the body that holds these instruments for oneself, thinking “I am it”, and so be deluded: that is Ajñāna.
As long as this body lasts, kleśas of many kinds keep pursuing him. It is of this that the śāstra has been warning: ‘Birth is sorrow, old age is sorrow, a wife is sorrow, again and again; at the end of life, great sorrow; so be watchful, be watchful.’ What is the state of this body like?
In childhood, joining with many, he is one with games and songs; when youth flowers, like the god whose bow is of flowers, he roams about, besotted with women; in middle age, sunk in the things of this world, he clings to the earning of money; when old age comes, with no thought of Murahari, he frets, “I have not this, I have not that”; unable to leave his many evil habits, with no wish to seek the path of Bhakti, fallen into the mire of karma, he crawls on, and man mixes his birth with the dust.